Publications

Methodology Papers for Rat Inhalation System

we are proud at

what we do

Methodology Papers for Rat Inhalation System
Lee, S., Schmidt, D., Tilders, F., Cole, M., Smith, A. and Rivier, C.L. (2000) Alcoholism: Clinical and Experimental Research. 24:110-122.
Prolonged Exposure to Intermittent Alcohol Vapors Blunts Hypothalamic Responsiveness to Immune and Non-Immune Signals
Effect of Repeated Exposure to Alcohol on the Response of the Hypothalamic-Pituitary-Adrenal Axis of the Rat:
II. Role of the Length and Regimen of Alcohol Treatment
Effect of Repeated Exposure to Alcohol on the Response of the Hypothalamic-Pituitary-Adrenal Axis of the Rat: II. Role of the Length and Regimen of Alcohol Treatment
Rivier, C.L. and Lee, S. (2001) Alcoholism: Clinical and Experimental Research. 25:106-111.
Methodology Paper for Mouse Inhalation System
Development of Individual Alcohol Inhalation Chambers for Mice: Validation in a Model of Prenatal Alcohol
Methodology Paper for Mouse Inhalation System
Kang, S.S., Cole, M., Lee, S. and Rivier, C.L. (2004) Alcoholism: Clinical and Experimental Research. 28:1549-1556.
Tolerance to hypothermic and antinoceptive effects of ∆9-tetrahydrocannabinol (THC) vapor inhalation in rats.
Repeated daily THC inhalation induces tolerance in female and male rats, providing further validation of the vapor inhalation method for preclinical studies.
To determine if tolerance to these effects can be produced with repeated vapor inhalation.
Effects of Δ9-THC and cannabidiol vapor inhalation in male and female rats.
In summary, the inhalation of THC or CBD, alone and in combination, produces approximately equivalent effects in male and female rats. This confirms the efficacy of the e-cigarette-based method of THC delivery in female rats.
Previous studies report sex differences in some, but not all, responses to cannabinoids in rats. The majority of studies use parenteral injection; however, most human use is via smoke inhalation and, increasingly, vapor inhalation.
THC inhalation reduced body temperature and increased tail-withdrawal latency in both sexes equivalently and in a concentration-dependent manner.
Compulsive-Like Sufentanil Vapor Self-Administration in Rats.
Opioid misuse is at historically high levels in the United States, with inhalation (ie, smoking and vaping) being one of the most common routes of consumption.
Compulsive-Like Sufentanil Vapor Self-Administration in Rats.
Opioid misuse is at historically high levels in the United States, with inhalation (ie, smoking and vaping) being one of the most common routes of consumption.
Intermittent Access to Ethanol Drinking Facilitates
Kimbrough A, Kim S, Cole M, Brennan M, George O. Alcohol Clin Exp Res. 2017 Aug;41(8):1502-1509. doi: 10.1111/acer.13434. Epub 2017 Jul 5.
The Transition to Excessive Drinking After Chronic Intermittent Ethanol Vapor Exposure.
Kimbrough A, Kim S, Cole M, Brennan M, George O. Alcohol Clin Exp Res. 2017 Aug;41(8):1502-1509. doi: 10.1111/acer.13434. Epub 2017 Jul 5.
Voluntary induction and maintenance of alcohol dependence in rats using alcohol vapor self-administration.
de Guglielmo G, Kallupi M, Cole MD, George O. Psychopharmacology (Berl). 2017 Jul;234(13):2009-2018. doi: 10.1007/s00213-017-4608-7. Epub 2017 Mar 24.
Voluntary induction and maintenance of alcohol dependence in rats using alcohol vapor self-administration.
de Guglielmo G, Kallupi M, Cole MD, George O. Psychopharmacology (Berl). 2017 Jul;234(13):2009-2018. doi: 10.1007/s00213-017-4608-7. Epub 2017 Mar 24.
Recruitment of a Neuronal Ensemble in the Central Nucleus of the Amygdala Is Required for Alcohol Dependence.
de Guglielmo G, Crawford E, Kim S, Vendruscolo LF, Hope BT, Brennan M, Cole M, Koob GF, George O. J Neurosci. 2016 Sep 7;36(36):9446-53. doi: 10.1523/JNEUROSCI.1395-16.2016.
Recruitment of a Neuronal Ensemble in the Central Nucleus of the Amygdala Is Required for Alcohol Dependence.
de Guglielmo G, Crawford E, Kim S, Vendruscolo LF, Hope BT, Brennan M, Cole M, Koob GF, George O. J Neurosci. 2016 Sep 7;36(36):9446-53. doi: 10.1523/JNEUROSCI.1395-16.2016.
Locomotor Stimulant and Rewarding Effects of Inhaling Methamphetamine
Nguyen JD, Aarde SM, Cole M, Vandewater SA, Grant Y, Taffe MA. Neuropsychopharmacology. 2016 Oct;41(11):2759-71. doi: 10.1038/npp.2016.88. Epub 2016 Jun 9.
Locomotor Stimulant and Rewarding Effects of Inhaling Methamphetamine
Nguyen JD, Aarde SM, Cole M, Vandewater SA, Grant Y, Taffe MA. Neuropsychopharmacology. 2016 Oct;41(11):2759-71. doi: 10.1038/npp.2016.88. Epub 2016 Jun 9.
Inhaled delivery of Δ(9)-tetrahydrocannabinol (THC) to rats by e-cigarette vapor technology.
Nguyen JD, Aarde SM, Vandewater SA, Grant Y, Stouffer DG, Parsons LH, Cole M, Taffe MA. Neuropharmacology. 2016 Oct;109:112-120. doi: 10.1016/j.neuropharm.2016.05.021. Epub 2016 May 30.
Inhaled delivery of Δ(9)-tetrahydrocannabinol (THC) to rats by e-cigarette vapor technology.
Nguyen JD, Aarde SM, Vandewater SA, Grant Y, Stouffer DG, Parsons LH, Cole M, Taffe MA. Neuropharmacology. 2016 Oct;109:112-120. doi: 10.1016/j.neuropharm.2016.05.021. Epub 2016 May 30.
Exposure to chronic intermittent nicotine vapor induces nicotine dependence.
George O, Grieder TE, Cole M, Koob GF. Pharmacol Biochem Behav. 2010 Jul;96(1):104-7. doi: 10.1016/j.pbb.2010.04.013. Epub 2010 Apr 24.
Exposure to chronic intermittent nicotine vapor induces nicotine dependence.
George O, Grieder TE, Cole M, Koob GF. Pharmacol Biochem Behav. 2010 Jul;96(1):104-7. doi: 10.1016/j.pbb.2010.04.013. Epub 2010 Apr 24.
Operant behavior and alcohol levels in blood and brain of alcohol-dependent rats.
Gilpin NW, Smith AD, Cole M, Weiss F, Koob GF, Richardson HN. Alcohol Clin Exp Res. 2009 Dec;33(12):2113-23. doi: 10.1111/j.1530-0277.2009.01051.x. Epub 2009 Sep 9. Erratum in: Alcohol Clin Exp Res. 2010 Feb;34(2):382.
Operant behavior and alcohol levels in blood and brain of alcohol-dependent rats.
Gilpin NW, Smith AD, Cole M, Weiss F, Koob GF, Richardson HN. Alcohol Clin Exp Res. 2009 Dec;33(12):2113-23. doi: 10.1111/j.1530-0277.2009.01051.x. Epub 2009 Sep 9. Erratum in: Alcohol Clin Exp Res. 2010 Feb;34(2):382.
Increased drinking during withdrawal from intermittent ethanol exposure is blocked by the CRF receptor antagonist D-Phe-CRF(12-41).
Finn DA, Snelling C, Fretwell AM, Tanchuck MA, Underwood L, Cole M, Crabbe JC, Roberts AJ. Alcohol Clin Exp Res. 2007 Jun;31(6):939-49. Epub 2007 Mar 31.
Increased drinking during withdrawal from intermittent ethanol exposure is blocked by the CRF receptor antagonist D-Phe-CRF(12-41).
Finn DA, Snelling C, Fretwell AM, Tanchuck MA, Underwood L, Cole M, Crabbe JC, Roberts AJ. Alcohol Clin Exp Res. 2007 Jun;31(6):939-49. Epub 2007 Mar 31.
Development of individual alcohol inhalation chambers for mice: validation in a model of prenatal alcohol.
Kang SS, Cole M, Lee S, Rivier C. Alcohol Clin Exp Res. 2004 Oct;28(10):1549-56.
Development of individual alcohol inhalation chambers for mice: validation in a model of prenatal alcohol.
Kang SS, Cole M, Lee S, Rivier C. Alcohol Clin Exp Res. 2004 Oct;28(10):1549-56.

Effects of nicotine and THC vapor inhalation administered by an electronic nicotine delivery system (ENDS) in male rats
Mehrak Javadi-Paydar, Tony M. Kerr, Eric L. Harvey, Maury Cole
Michael A. Taffe,
Effects of nicotine and THC vapor inhalation administered by an electronic nicotine delivery system (ENDS) in male rats
Mehrak Javadi-Paydar, Tony M. Kerr, Eric L. Harvey, Maury Cole
Michael A. Taffe,
Controlled and behaviorally relevant levels of oral ethanol intake in rhesus macaques using a flavorant-fade procedure.
Katner SN, Flynn CT, Von Huben SN, Kirsten AJ, Davis SA, Lay CC, Cole M, Roberts AJ, Fox HS, Taffe MA. Alcohol Clin Exp Res. 2004 Jun;28(6):873-83.
Controlled and behaviorally relevant levels of oral ethanol intake in rhesus macaques using a flavorant-fade procedure.
Katner SN, Flynn CT, Von Huben SN, Kirsten AJ, Davis SA, Lay CC, Cole M, Roberts AJ, Fox HS, Taffe MA. Alcohol Clin Exp Res. 2004 Jun;28(6):873-83.
Do You Feel It Now? Route of Administration and 9-Tetrahydrocannabinol-Like Discriminative Stimulus Effects of Synthetic Cannabinoids in Mice
Jenny L. Wiley, Timothy W. Lefever, M.A. Michelle
Glass, Brian F. Thomas
Do You Feel It Now? Route of Administration and 9-Tetrahydrocannabinol-Like Discriminative Stimulus Effects of Synthetic Cannabinoids in Mice
Jenny L. Wiley, Timothy W. Lefever, M.A. Michelle
Glass, Brian F. Thomas

0